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CONSERT - Concerted Safety and Efficiency Evaluation of Retroviral Transgenesis for Gene Therapy of Inherited Diseases


  • Abstract:
    In its experimental phase, genetic therapy is an extension of the clinical research on humans, on which the schemes used for research on pharmaceuticals and the ethical examination of the latter cannot be applied by implication. An ethical analysis of genetic therapy requires a consideration of individual cases as well as of the underlying research strategies. Since November 2005, in its sixth Framework Programme the European Commission has been funding a large European network project in regards to the genetic therapy of inherited diseases. In this program, safety researchers and virologists get together with clinical practitioners (Concerted Safety and Efficiency Evaluation of Retroviral Transgenesis for Gene Therapy of Inherited Diseases, CONSERT). To act on the suggestion of physicians and scientists involved, the Institute for Science and Ethics has adopted a sub-project, which has as its subject the analysis of the ethical questions closely connected to genetic therapy. The first interchange between the scientists involved took place at a meeting in Leukerbad (Switzerland) in January 2005.

  • Head of the project’s ethical sections:
    PD Dr. phil. Michael Fuchs
    Institute of Science and Ethics, Bonn
    Phone: +49 (0)228 / 3364-1921  and -1920
    Fax:  +49 (0)228 / 3364-1950
    eMail: [Email protection active, please enable JavaScript.]



  • Funding:
    Sixth Framework Programme of the European Commission


  • Funding period:
    November 2005 - October 2009


  • Partners:

    Cor Oosterwijk, European Genetic Alliances Network, Brussels

    Christopher Baum, Hannover Medical School, Hanover
    Christof v. Kalle, MD, Translational Oncology DKFZ, NCT-Heidelberg
    Klaus Kühlcke, Eufers AG, Idar-Oberstein
    Michael Fuchs, Institute of Science and Ethics, Bonn
    Peter Pohl, GATC Biotech AG, Konstanz
    Manuel Grez, Georg-Speyer-Haus, Frankfurt

    François-Loïc Cosset, INSERM, Lyon
    Alain Fischer & Marina Cavazzana-Calvo, INSERM, Paris
    Anne Galy , Généthon, Evry
    William Saurin, Genomining, Montrouge

    Nicholas Anagnou, University of Athens, Athens
    George Vassilopoulos, Medical and Biological Research, Academy of Athens

    Great Britain:
    Adrian Thrasher, Insitute of Child Health, University College London
    Mary Collins, University College London

    Fulvio Mavilio, Molecular Medicine S.p.A, Milan
    Luigi Naldini, Fondazione Centro San Raffaele del Monte Tabor, Milan
    Maria Grazia Roncarolo, Università Vita-Salute san Raffaele, Milan

    The Netherlands:

    Gerard Wagemaker (Koordinator), Erasmus MC Rotterdam
     Louise van den Bos, Science & Technology Transfer Rotterdam

    Stefan Karlsson, Lunds Universitet, Lund

    Didier Trono, EPLF, Lausanne

    Jordi Barquinero, Centre de Transfució i Banc de Teixit, Barcelona
    Juan Bueren, CIEMAT, Madrid


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